Precision Nanosystems NanoAssemblr Blaze

Description

The Precision Nanosystems NanoAssemblr Blaze offers several key features designed to enhance lipid nanoparticle production. Powered by NxGen technology, it provides controlled mixing conditions and consistent flow rates, ensuring robust particle formation. The system supports a wide range of sample volumes, from 10 mL to 1 L, and uses single-use NxGen cartridges for efficient operation. Total flow rates range from 4 to 115 mL per minute, enabling high-performance processing.

The nanoparticle formulation system is capable of tangential flow filtration (TFF) and sterile filtration. The NanoAssemblr system also supports fill/finish operations and in-line dilution, with dilution ratios ranging from 1:1 to 4:1. In-line pressure monitoring and a short run time further improve operational efficiency. The NanoAssemblr Blaze is scalable and supports the seamless technology transfer of critical process parameters (CPPs) to the NanoAssemblr Commercial Formulation System and cGMP facilities, making it ideal for commercial applications.

The Blaze process development system has generous environmental conditions: temperature range of 15°C to 35°C, humidity between 30% and 65% (non-condensing), and a pressure range of 70 kPa to 106 kPa.

Key Features of the Precision Nanosystems NanoAssemblr Blaze:

NxGen Technology
- Controlled Mixing Conditions
- Consistent Flow Rates – Robust Particle Formation
Sample Volume Range 10 mL to 1 L
Single-Use NxGen Cartridges
Total Flow Rate 4 to 115 mL/min
Tangential Flow Filtration (TFF)
Sterile Filtration
Fill/Finish Operations
In-Line Dilution
Dilution Ratio 1:1 to 4:1
In-Line Pressure Monitoring
Short Run Time
Scalable System
- Technology Transfer of Critical Process Parameters (CPPs) to NanoAssemblr Commercial Formulation System & cGMP Facility
Environmental Conditions:
- Temperature 15°C to 35°C
- Humidity 30% to 65% (Non-Condensing)
- Pressure 70kPa to 106kPa

Common Applications:

Process development of lipid nanoparticles (LNPs) such as…

Early CMC Studies
Large-Scale Protocol Development of Upstream & Downstream Operations

Select a Nanomedicine Candidate: With Blaze, preclinical studies can be conducted efficiently with a process that mirrors a clinical scale implementation.
Identify a Scalable Manufacturing Process: By using Blaze, process development can be conducted on both the upstream and downstream steps in the drug development.

*Precision Nanosystems are now Cytiva

Brochure for the NanoAssemblr Blaze

Brochure for the NanoAssemblr Commercial Formulation System

Data Sheet for the NanoAssemblr Blaze

Manual for the NanoAssemblr Blaze